Serrano Lab

PUBLICATIONS (2020-2008)

 

Beeler JA, Mourra DA, Zanca RM, Kalmbach A, Gellman C, Klein BY, Ravenelle R, Serrano PA, Moore H, Rayport S, Mingote S, Burghardt NS. (2020) Vulnerable and Resilient Phenotypes in a Mouse Model of Anorexia Nervosa. Biological Psychiatry, in press.

 

Aubry AV, Serrano PA, Burghardt NS. Molecular Correlates of Stress-Induced Increases in Fear Memory Consolidation within the Amygdala. In: Jose Fernando Maya-Vetencourt, editor. Prime Archives in Neuroscience. Hyderabad, India: Vide Leaf. 2020. 

 

Avila JA, Kiprowska M, Jean-Louis T, Rockwell P, Figueiredo-Pereira ME, Serrano PA. PACAP27 mitigates an age-dependent hippocampal vulnerability to PGJ2-induced spatial learning deficits and neuroinflammation in mice. Brain and Behavior [Online ahead of print]  e01465  2019 Nov 25

 

Opendak M, Robinson-Drummer P, Blomkvist A, Zanca RM, Wood K, Jacobs L, Chan S, Tan S, Woo J, Venkataraman G, Kirschner E, Lundström JN, Wilson DA, Serrano PA, Sullivan RM.  Neurobiology of maternal regulation of infant fear: the role of mesolimbic dopamine and its disruption by maltreatment.  Neuropsychopharmacology. 2019 Feb 13. doi: 10.1038/s41386-019-0340-9. [Epub ahead of print] PMID:30758321

 

Corwin C, Nikolopoulou A, Pan AL, Nunez-Santos M, Vallabhajosula S, Serrano PA, Babich J and Figueiredo-Pereira ME. Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets. Journal of Neuroinflmmation, https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1305-3 [Epub ahead of print]

 

Opendak M, Zanca RM, Anane E, Serrano PA, Sullivan RM. Developmental transitions in amygdala PKC isoforms and AMPA receptor expression associated with threat memory in infant rats. Science Reports. 2018 Oct 2;8(1):14679. doi: 10.1038/s41598-018-32762-y. PMID:30279521.

 

Zanca RM, Sanay S, Avila JA, Rodriguez E, Shair HN and Serrano PA. Contextual fear memory modulates PSD95 phosphorylation, AMPAr subunits, PKMzeta and PI3K differentially between adult and juvenile rats. Neurobiology of Stress, Feb 2019.

 

Dugue R, Hassen GW, Shulman A, Goodman JH, Michelson H, Serrano PA, Chauhan S, Ling DSF. Controlled cortical impact-induced neurodegeneration decreases after administration of the novel calpain-inhibitor Gabadur. Brain Res Bull. 2018 Aug 24. pii: S0361-9230(18)30327-7. doi:10.1016/j.brainresbull.2018.08.016. [Epub ahead of print]

 

Luine V, Serrano PA., & Frankfurt M. (2018). Rapid effects on memory consolidation  and spine morphology by estradiol in female and male rodents. Hormones and Behavior; 104: 111–118.

 

Avila JA, Zanca RM, Shor D, Paleologos N, Alliger AA, Figueiredo-Pereira ME, Serrano PA. Chronic voluntary oral methamphetamine induces deficits in spatial learning and hippocampal protein kinase Mzeta with enhanced astrogliosis and cyclooxygenase-2 levels. Heliyon. 2018 Feb 2;4(2):e00509. doi: 10.1016/j.heliyon.2018.e00509. eCollection 2018 Feb.

 

Luine V, Bowman R and Serrano PA. Sex differences in cognitive responses to stress in rodents in Handbook of Research on Object Novelty Recognition.  Edited by Abdel Ennaceur.  Elsevier/Academic Press (2018).

 

Avila JA, Alliger AA, Carvajal B, Zanca RM, Serrano PA. and Luine VN. Estradiol rapidly increases GluA2-mushroom spines and decreases GluA2-filopodia spines in hippocampus CA1. Hippocampus, 2017 Aug 17. doi: 10.1002/hipo.22768.

 

Iniguez SD, Flores-Ramirez FJ, Riggs LM, Alipio JB, Garcia I, Hernandez MA, Sanchez DO, Lobo MK, Serrano PA, Braren SH, Castillo SA. Vicarious social defeat stress induces depression-related outcomes in female mice. Biological Psychiatry, 2017 Jul 29. pii: S0006-3223(17)31814-0. doi: 10.1016/j.biopsych.2017.07.014. [Epub ahead of print].

 

Hsieh C, Tsokas P, Serrano PA, Hernández AI, Tian D, Cottrell JE, Shouval HZ, Fenton AA, Sacktor TC. Persistent increased PKMζ in long-term and remote spatial memory. Neurobiology of learning and memory. 2017; 138:135-144. PMID: 27417578

 

Repeated recall and PKMζ maintain fear memories in juvenile rats. Oliver CF, Kabitzke P, Serrano PA, Egan LJ, Barr GA, Shair HN, Wiedenmayer C. Learning & Memory (Cold Spring Harbor, N.Y.). 2016; 23(12):710-713. PMID: 27918276

 

Social defeat stress induces depression-like behavior and alters spine morphology in the hippocampus of adolescent male C57BL/6 mice. Iñiguez SD, Aubry A, Riggs LM, Alipio JB, Zanca RM, Flores-Ramirez FJ, Hernandez MA, Nieto SJ, Musheyev D, Serrano PA. Neurobiology of stress. 2016; 5:54-64. PMID: 27981196

Molecular Mechanisms of Stress-Induced Increases in Fear Memory Consolidation within the Amygdala. Aubry AV, Serrano PA, Burghardt NS. Frontiers in behavioral neuroscience. 2016; 10:191. PMID: 27818625

 

Zanca RM, Braren SH, Maloney B, Schrott LM, Luine VN, Serrano PA. (2015) Environmental enrichment increases hippocampal glucocorticoid receptors and decreases GluA2 and protein kinase M zeta (PKMz) trafficking during chronic stress: A protective mechanism?  Frontiers in Behavioral Neuroscience, Nov 12;9:303. doi: 10.3389/fnbeh.2015.00303. eCollection 2015. 

 

Figueiredo-Pereira ME, Rockwell P, Schmidt-Glenewinkel T, Serrano PA. (2014) Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegeneration.  Frontiers in Molecular Neuroscience, 7:104. doi: 10.3389/fnmol.2014.00104. eCollection

 

Braren SH, Drapala D, Tulloch IK, Serrano PA. Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects Protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors (2014) Frontiers in Behavioral Neuroscience, 8;438. doi: 10.3389/fnbeh.2014.00438. eCollection 2014.

 

Sebastian V, Vergel T, Baig R, Schrott LM, Serrano PA. (2013a) PKMζ differentially utilized between sexes for remote long-term spatial memory.  PloS One, 11;8:e81121. doi: 10.1371/journal.pone.0081121.

 

Sebastian, V, Estil, J, Chen, D, Schrott, LM, Serrano PA. (2013b) Acute Physiological Stress Promotes Spine Maturation and Synaptic Clustering in the Hippocampus.  PLoS One, 24;8:e79077. doi: 10.1371/journal.pone.0079077.

 

Sebastian V, Diallo A, Ling DSF, Serrano PA. (2013c) Robust training attenuates TBI-induced deficits in reference and working memory on the radial 8-arm maze.  Frontiers in Behavioral Neuroscience. 7:38. doi: 10.3389/fnbeh.2013.00038.

 

 Gomez JL, Lewis MJ, Sebastian V, Serrano PA, Luine VN.  (2013) Alcohol administration blocks stress-induced impairments in memory and anxiety, and alters hippocampal neurotransmitter receptor expression in male rats.  Hormones & Behavior, 63:659-66.

 

Eilam-Stick, T, Serrano PA, Fankfurt M, Luine VN (2011) Bisphenol-A impairs memory and reduces dendritic spine density in adult male rats. Behavioral Neuroscience, 126(1):175-85.

 

Serrano PA, Friedman EL, Kenney J, Taubenfeld SM, Zimmerman JM, Alberini C, Kelley AE, Maren S, Yin JCP, Sacktor TC, Fenton AA. (2008) PKMz maintains spatial, instrumental, and classically-conditioned long-term memory: implications for the treatment of memory-related disorders. PLoS Biology 6, 2698-2706.

 

Yao Y, Kelly MT, Sakimura S, Serrano PA, Tian D, Bergold P, Frey J, Sacktor TC. (2008) PKMz maintains late-LTP by enhancing NSF/GluR2-mediated trafficking of postsynaptic AMPARs. Journal of Neuroscience 28, 7820-7.

 

Schrott LM, Franklin LT, Serrano PA. (2008) Acquisition of Radial Arm Maze is Impaired Following Prenatal Opiate Exposure Potential Role of Brain Derived Neurotrophic Factor. Brain Research, 1198, 132-140.

 

PUBLICATIONS (2000-2008)

 

*Pastalkova, E, *Serrano PA, Pinkhasova D, Wallace E, Fenton A, Sacktor TC.  (2006) Spatial information storage by the maintenance mechanism of LTP.  Science, 313, 1141-1144. *authors contributed equally to this work.

 

Cracco J, Serrano PA, Moskowitz SI, Bergold PJ, Sacktor TC. (2005) Protein synthesis-dependent LTP in isolated dendrites of CA1 pyramidal cells.  Hippocampus, 15, 551-556.

 

Serrano PA, Yao Y, Sacktor TC. (2005) Persistent phosphorylation by protein kinase Mz maintains late phase long-term potentiation.  Journal of Neuroscience 25, 1979-1984.

 

Hernandez IA, Blace N, Crary JF, Serrano PA, Leitges, Libien JL, Weinstein G, Tcherepanov A, Sacktor TC. (2003) PKMz synthesis from a brain mRNA encoding an independent PKCz catalytic domain:  implications for the molecular mechanism of memory.  Journal of Biological Chemistry, 278, 40305-40316.

 

Ling DS, Benardo LS, Serrano PA, Blace N, Kelly MT, Crary JF, Sacktor TC.  (2002) Persistently active protein kinase M is both necessary and sufficient for maintaining long-term potentiation.  Nature Neuroscience 5, 295-6.

 

Hrabetova S, Serrano PA, Blace N, Tse H, Jane D, Monaghan D, Sacktor TC. (2000)  Distinct NMDA receptor subpopulations contribute to long-term potentiation and long-term depression.  Journal of Neuroscience, 20, RC81-6.

 

Routtenberg A, Cantallops I, Zaffuto S, Serrano PA, Namgung U. (2000) Enhanced learning after genetic overexpression of a brain growth protein. Proceedings of the National Academy of Science, 97, 7657-7662.

 

PUBLICATIONS (1991-1999)

 

Serrano PA, Rodriguez WA, Bennett EL, Rosenzweig MR. (1995) Protein kinase inhibitors disrupt memory formation in two chick brain regions.  Pharmacology, Biochemistry and Behavior, 52, 547-554.

 

Serrano PA, Rodriguez WA, Pope B, Bennett EL, Rosenzweig MR.  (1995) Protein kinase C inhibitor chelerythrine disrupts memory formation in chicks. Behavioral Neuroscience, 109, 278-284.

 

Serrano PA, Beniston DS, Oxonian MG, Rodriguez WA, Rosenzweig MR, Bennett EL. (1994) Differential effects of PKC inhibitors and activators on memory formation in the 2-day-old chick.  Behavioral and Neural Biology, 61, 60-72.

 

Rosenzweig MR, Bennett EL, Colombo PJ, Lee DW, Serrano PA. (1993) Short-term, intermediate-term, and long-term memories.  Behavioral Brain Research, 57, 193-198.

 

Serrano PA, Ramus SJ, Bennett EL, Rosenzweig MR. (1992) Comparative study of roles of the lobus parolfactorius and intermediate mediale hyperstriatum ventrale in memory formation in the chick brain.  Pharmacology, Biochemistry and Behavior, 41, 761-766

 

Rosenzweig MR, Bennett EL, Martinez JL, Colombo PJ, Lee DW, Serrano PA. (1992)  Studying stages of memory formation with chicks.  In L.R. Squire and N. Butters (Eds.), Neuropsychology of Memory (2nd ed.) (pp. 533-546).  New York:  Guilford.

 

Rosenzweig MR, Bennett EL, Martinez JL, Beniston DB, Colombo PJ, Lee DW, Patterson TA, Schulteis G, Serrano PA. (1991) Stages of memory formation in the chick:  Findings and problems.  In R.J. Andrew (Ed.), Neural and Behavioural Plasticity in the Domestic Chick (pp. 394-418).  Oxford:  Oxford University Press.

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